What is multisystem inflammatory syndrome in children (MIS-C)?

Multisystem inflammatory syndrome in children (MIS-C) is a serious condition in which some parts of the body — such as the heart, lungs, blood vessels, kidneys, digestive system, brain, skin or eyes — become severely inflamed. Evidence indicates that many of these children were infected with the COVID-19 virus in the past, as shown by positive antibody test results, suggesting that MIS-C is caused by an excessive immune response related to COVID-19.

Possible signs and symptoms of MIS-C include:

• Fever that lasts 24 hours or longer
• Vomiting
• Diarrhea
• Pain in the stomach
• Skin rash
• Fast heartbeat
• Rapid breathing
• Red eyes
• Redness or swelling of the lips and tongue
• Feeling unusually tired
• Redness or swelling of the hands or feet
• Headache, dizziness or lightheadedness
• Enlarged lymph nodes

Emergency warning signs of MIS-C include:

• Inability to wake up or stay awake
• Difficulty breathing
• New confusion
• Pale, gray or blue-colored skin, lips or nail beds — depending on skin tone
• Severe stomach pain

If your child shows any emergency warning signs or is severely sick with other signs and symptoms, take your child to the nearest emergency department or call 911 or your local emergency number. If your child isn't severely ill but shows other signs or symptoms of MIS-C, contact your child's doctor right away for advice.